USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P17844 USC-OGP 2-DE database:  P17844 P17844 General information about the entry View entry in simple text format Entry name DDX5_HUMAN Primary accession number P17844 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Probable ATP-dependent RNA helicase DDX5; EC=3.6.4.13; AltName: Full=DEAD box protein 5; AltName: Full=RNA helicase p68;. Gene name Name=DDX5 Synonyms=G17P1, HELR, HLR1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1127: pI=5.58; Mw=72168 SPOT OGP-1312: pI=5.04; Mw=21529 Cross-references UniProtKB/Swiss-Prot P17844; DDX5_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name DDX5_HUMAN Primary accession number P17844 Secondary accession number(s) B4DLW8 B5BU21 D3DU32 E7ETL9 O75681 Q53Y61 Sequence was last modified on  August 1, 1990 (version 1) Annotations were last modified on  March 15, 2017 (version 195) Name and origin of the protein Description RecName: Full=Probable ATP-dependent RNA helicase DDX5; EC=3.6.4.13; AltName: Full=DEAD box protein 5; AltName: Full=RNA helicase p68; Gene name Name=DDX5 Synonyms=G17P1, HELR, HLR1 Encoded on Name=DDX5; Synonyms=G17P1, HELR, HLR1 Keywords 3D-structure; Acetylation; Alternative splicing; ATP-binding; Biological rhythms; Complete proteome; Helicase; Hydrolase; Isopeptide bond; mRNA processing; mRNA splicing; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; RNA-binding; Spliceosome; Transcription; Transcription regulation; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X52104; CAA36324.1; -; mRNA EMBL AF015812; AAB84094.1; -; Genomic_DNA EMBL BT006943; AAP35589.1; -; mRNA EMBL AK297192; BAG59680.1; -; mRNA EMBL AB451257; BAG70071.1; -; mRNA EMBL AC009994; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471109; EAW94202.1; -; Genomic_DNA EMBL CH471109; EAW94203.1; -; Genomic_DNA EMBL BC016027; AAH16027.1; -; mRNA EMBL X15729; CAA33751.1; -; mRNA EMBL AJ010931; CAA09408.1; -; Genomic_DNA CCDS CCDS11659.1; -. [P17844-1]; . PIR JC1087; JC1087; . RefSeq NP_001307524.1; NM_001320595.1. [P17844-1]; . RefSeq NP_001307525.1; NM_001320596.1. [P17844-1]; . RefSeq NP_004387.1; NM_004396.4. [P17844-1]; . UniGene Hs.279806; -; . PDB 3FE2; X-ray; 2.60 A; A/B=68-307 PDB 4A4D; X-ray; 2.70 A; A=52-304 PDBsum 3FE2; -; . PDBsum 4A4D; -; . ProteinModelPortal P17844; -; . SMR P17844; -; . BioGrid 108021; 215; . DIP DIP-29844N; -; . IntAct P17844; 116; . MINT MINT-5000516; -; . STRING 9606.ENSP00000225792; -; . iPTMnet P17844; -; . PhosphoSitePlus P17844; -; . SwissPalm P17844; -; . BioMuta DDX5; -; . DMDM 129383; -; . SWISS-2DPAGE P17844; -; . EPD P17844; -; . MaxQB P17844; -; . PaxDb P17844; -; . PeptideAtlas P17844; -; . PRIDE P17844; -; . DNASU 1655; -; . Ensembl ENST00000225792; ENSP00000225792; ENSG00000108654. [P17844-1]; . Ensembl ENST00000450599; ENSP00000403085; ENSG00000108654. [P17844-2]; . GeneID 1655; -; . KEGG hsa:1655; -; . UCSC uc002jek.3; human. [P17844-1]; . CTD 1655; -; . DisGeNET 1655; -; . GeneCards DDX5; -; . GeneCards MIR3064; -; . GeneCards MIR5047; -; . HGNC HGNC:2746; DDX5; . HPA CAB005868; -; . HPA HPA020043; -; . MIM 180630; gene; . neXtProt NX_P17844; -; . OpenTargets ENSG00000108654; -; . PharmGKB PA27228; -; . eggNOG KOG0331; Eukaryota; . eggNOG COG0513; LUCA; . GeneTree ENSGT00820000126976; -; . HOGENOM HOG000268804; -; . HOVERGEN HBG015893; -; . InParanoid P17844; -; . KO K12823; -; . PhylomeDB P17844; -; . TreeFam TF300332; -; . BRENDA 3.6.4.13; 2681; . Reactome R-HSA-72163; mRNA Splicing - Major Pathway; . SIGNOR P17844; -; . ChiTaRS DDX5; human; . EvolutionaryTrace P17844; -; . GeneWiki DDX5; -; . GenomeRNAi 1655; -; . PRO PR:P17844; -; . Proteomes UP000005640; Chromosome 17; . Bgee ENSG00000108654; -; . CleanEx HS_DDX5; -; . ExpressionAtlas P17844; baseline and differential; . Genevisible P17844; HS; . GO GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0031012; C:extracellular matrix; IDA:BHF-UCL; . GO GO:0030529; C:intracellular ribonucleoprotein complex; IDA:MGI; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005730; C:nucleolus; IDA:UniProtKB; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0050681; F:androgen receptor binding; IDA:UniProtKB; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0004004; F:ATP-dependent RNA helicase activity; IBA:GO_Central; . GO GO:0030331; F:estrogen receptor binding; IDA:UniProtKB; . GO GO:0003730; F:mRNA 3'-UTR binding; IDA:UniProtKB; . GO GO:0036002; F:pre-mRNA binding; IDA:UniProtKB; . GO GO:0043021; F:ribonucleoprotein complex binding; IDA:UniProtKB; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0003724; F:RNA helicase activity; IMP:UniProtKB; . GO GO:0003713; F:transcription coactivator activity; IDA:UniProtKB; . GO GO:0016049; P:cell growth; NAS:UniProtKB; . GO GO:0072332; P:intrinsic apoptotic signaling pathway by p53 class mediator; IMP:UniProtKB; . GO GO:0000398; P:mRNA splicing; via spliceosome; IC:UniProtKB GO GO:0009299; P:mRNA transcription; IMP:CACAO; . GO GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB; . GO GO:0000956; P:nuclear-transcribed mRNA catabolic process; IDA:UniProtKB; . GO GO:0043517; P:positive regulation of DNA damage response; signal transduction by p53 class mediator; IMP:UniProtKB GO GO:0033148; P:positive regulation of intracellular estrogen receptor signaling pathway; IDA:UniProtKB; . GO GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB; . GO GO:0000381; P:regulation of alternative mRNA splicing; via spliceosome; IDA:UniProtKB GO GO:0060765; P:regulation of androgen receptor signaling pathway; IMP:UniProtKB; . GO GO:0045667; P:regulation of osteoblast differentiation; ISS:UniProtKB; . GO GO:2001014; P:regulation of skeletal muscle cell differentiation; ISS:UniProtKB; . GO GO:0045069; P:regulation of viral genome replication; IEA:Ensembl; . GO GO:0048511; P:rhythmic process; IEA:UniProtKB-KW; . GO GO:0010501; P:RNA secondary structure unwinding; IBA:GO_Central; . Gene3D 3.40.50.300; -; 2; . InterPro IPR011545; DEAD/DEAH_box_helicase_dom; . InterPro IPR014001; Helicase_ATP-bd; . InterPro IPR001650; Helicase_C; . InterPro IPR027417; P-loop_NTPase; . InterPro IPR012587; P68_rpt; . InterPro IPR000629; RNA-helicase_DEAD-box_CS; . InterPro IPR014014; RNA_helicase_DEAD_Q_motif; . Pfam PF00270; DEAD; 1; . Pfam PF00271; Helicase_C; 1; . Pfam PF08061; P68HR; 2; . SMART SM00487; DEXDc; 1; . SMART SM00490; HELICc; 1; . SMART SM01414; P68HR; 2; . SUPFAM SSF52540; SSF52540; 1; . PROSITE PS00039; DEAD_ATP_HELICASE; 1; . PROSITE PS51192; HELICASE_ATP_BIND_1; 1; . PROSITE PS51194; HELICASE_CTER; 1; . PROSITE PS51195; Q_MOTIF; 1; .

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